September 1, 1995AJP Regulatory Integrative and Comparative Physiology

Interactions between angiotensin and nitric oxide in the renal response to volume expansion

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Why the study?

How do nitric oxide and angiotensin II interact to mediate the renal response to extracellular volume expansion in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Intrarenal maintenance of ANG II levels… vs Different experimental conditions comparing…

Design

Preclinical

Authors

MLMaría T. LlinásInstituto Murciano de Investigación Biosanitaria JGJuan D. GonzálezClinica Universidad de Navarra FSF. Javier SalazarHospital Universitario Virgen de las Nieves

Discussion

Member takes

Implication

These dog data suggest NO tempers ANG II antinatriuresis during volume expansion; leaves open translation to human renal sodium handling.

Structured PICO

How do nitric oxide and angiotensin II interact to mediate the renal response to extracellular volume expansion in anesthetized dogs?

Population

Anesthetized dogs

Intervention

Intrarenal maintenance of ANG II levels, intrarenal NO synthesis inhibition, ANG II synthesis inhibition during NO synthesis blockade, or NO synthesis inhibition during intrarenal maintenance of ANG II levels

Comparator

Different experimental conditions (groups 1-4) comparing various states of NO and ANG II synthesis/maintenance

Outcome

Renal hemodynamics, sodium excretion, fractional lithium excretion (FeLi), and renal blood flow in response to extracellular volume expansion (ECVE)surrogate

Endogenous nitric oxide modulates the vasoconstrictor and antinatriuretic effects of angiotensin II during extracellular volume expansion.

Cite This Study

Llinás et al. (1995) studied this question.

synapsesocial.com/papers/6a716a5e84cc45bb7bdff09f https://doi.org/10.1152/ajpregu.1995.269.3.r504

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Interactions between angiotensin and nitric oxide in the renal response to volume expansion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interactions between angiotensin and nitric oxide in the renal response to volume expansion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider