Key result
Fatty infiltration grade on T1WI muscle MRI showed significant positive correlations with clinical functional score grades in 17 of 31 evaluated muscles in boys with Duchenne muscular dystrophy.
Why the study?
Does muscle Magnetic Resonance Imaging (MRI) effectively evaluate muscle preservation compared to clinical function and muscle biopsy in patients with Duchenne muscular dystrophy?
Cross-Sectional (n=31)
No
Does muscle Magnetic Resonance Imaging (MRI) effectively evaluate muscle preservation compared to clinical function and muscle biopsy in patients with Duchenne muscular dystrophy?
Muscle MRI is highlighted as a noninvasive alternative to muscle biopsy for evaluating muscle preservation in patients with Duchenne muscular dystrophy.
Muscle MRI may support noninvasive DMD monitoring; hypothesis-generating and requires validation before practice change.
Impairment in patients with Duchenne muscular dystrophy (DMD) has been evaluated primarily by muscle fiber microscopy examination. Pathologic examination is limited by the choice of muscle and the invasiveness of muscle biopsy. Magnetic resonance imaging (MRI) of the muscle is a noninvasive method of evaluating muscle preservation.
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Li et al. (2019) conducted a cross-sectional in Duchenne Muscular Dystrophy (n=31). Muscle MRI (T1WI fatty infiltration grade) vs. Clinical functional score grades was evaluated on Correlation between T1WI fatty infiltration grade and clinical functional grade. Fatty infiltration grade on T1WI muscle MRI showed significant positive correlations with clinical functional score grades in 17 of 31 evaluated muscles in boys with Duchenne muscular dystrophy.
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