Patent Evaluation: Novel 2,2′-alkylenediindoles as anti-ulcer agents

SummaryNovelty: Novel 2,2′-alkylenediindole derivatives are claimed to be H+/K+ ATPase inhibitors. They are potentially useful as anti-ulcer agents.Biology: An H+/K+ ATPase inhibitory activity assay was performed in vitro using a pig stomach preparation. Inhibition was determined colorimetrically. Results are given for twelve compounds. ATPase inhibition was 5-100% (dose 5–20 μg/ml).Chemistry: A total of twenty-three compounds are disclosed. Syntheses are given in five examples. Characterization is by 1H nmr and ms. None of the compounds are specifically claimed. 3-(2-Phenylethylaminoethyl)-2,2′-tetramethylenediindole is typical of the claim.