Key result
Normal BP control linked to ~56% lower risk of mild cognitive impairment.
Why the study?
There is limited information on the association of hypertension duration, treatment, control, and lifestyle risk factors with mild cognitive impairment in hypertensive patients.
Does controlling blood pressure to normal target values and modifying lifestyle factors reduce the incidence of mild cognitive impairment in middle-aged and elderly patients with hypertension?
Case-Control (n=572)
Does controlling blood pressure to normal target values and modifying lifestyle factors reduce the incidence of mild cognitive impairment in middle-aged and elderly patients with hypertension?
Odds Ratio: 0.44 (95% CI 0.3–0.65)
Controlling blood pressure to normal targets and managing lifestyle factors are associated with a lower risk of mild cognitive impairment in middle-aged and elderly hypertensive patients.
Supports normal BP targets in hypertensives to potentially lower MCI risk; hypothesis-generating, requires randomized confirmation.
Background: Epidemiological studies suggest that the incidence of hypertension in China is causally related to cognitive impairment. However, there is a dearth of information available regarding important factors for the association, including disease duration, therapeutic options, and risk factors associated with mild cognitive impairment (MCI) in patients with hypertension. Methods: We selected a diverse cohort of 572 patients with hypertension and assessed cognitive function using MoCA. Potential risk factors were investigated by a structured questionnaire. Risk factors associated with the hypertension-induced MCI occurring conversion of were analyzed using multifactorial regression analysis. Results: MCI was observed in 256 of 572 individuals, which increased with age (OR=1.15, 95% CI 1.10-1.20), but was decreased with high education status (OR=0.47, 95% CI 0.32-0.71). Risk factors independently associated with MCI were diabetes (OR=2.40, 95% CI 1.53-3.76), hyperlipidemia (OR=1.49, 95%=1.01-2.16), high salt diet (OR=2.27, 95% CI 1.34-3.84), and physical activity:>2h/week (OR=0.65, 95%0.44-0.94). However, controlling blood pressure to "normal" target values helped decrease the incidence of MCI (OR=0.44, 95% CI 0.30-0.65): this was not age dependent. Conclusion: Our results suggest that it is necessary to promote the education of the middle-aged and elderly Chinese population to correctly and effectively use anti-hypertensives to control hypertension to a normal range to prevent cognitive.
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A 2022 study conducted a case-control in Hypertension and mild cognitive impairment (n=572). Controlling blood pressure to normal target values vs. Uncontrolled blood pressure was evaluated on Incidence of mild cognitive impairment (MCI) (OR 0.44, 95% CI 0.30-0.65). Controlling blood pressure to normal target values was associated with a decreased incidence of mild cognitive impairment (OR 0.44; 95% CI 0.30-0.65).
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