Key result
A 23-year-old man with Coxsackie B4 rhabdomyolysis presented with extreme creatine kinase elevation (650,000 U/L) and was treated with vigorous hydration and indomethacin.
This case report highlights an extreme elevation of creatine kinase in a patient with virus-associated rhabdomyolysis.
Answers are grounded in this paper and cite their sources.
Single-case link suggests possible TNF involvement in viral rhabdomyolysis; leaves open causal role and clinical relevance.
Letters15 October 1993Tumor Necrosis Factor and Coxsackie B4 RhabdomyolysisRobert J. Konrad, MD, David B. P. Goodman, MD, and Walter L. Davis, MDRobert J. Konrad, MD, David B. P. Goodman, MD, and Walter L. Davis, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-8-199310150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 23-year-old man presented with sore throat, diffuse muscle pain and weakness, enlarged tonsils, cervical lymphadenopathy, and myoglobinuria. His leukocyte count was 14.6 109/L; his lactate dehydrogenase concentration was 8200 U/L; his aspartate aminotransferase level was 2601 U/L; and his creatine kinase concentration was 650 000 U/L. Only twice previously have higher creatine kinase elevations been reported in virus-associated rhabdomyolysis [1, 2].Table 1. Superoxide Release after 2 Hours Incubation Assayed by Spectrophotometric Measurement* The patient was hydrated vigorously and was given indomethacin for pain ...References1. Tanaka T, Takada T, Takagi D, Takeyama N, Kitazawa Y. Acute renal failure due to rhabdomyolysis associated with Echovirus 9 infection: a case report and review of literature. Jpn J Med. 1989; 28:237-42. Google Scholar2. Fukuyama Y, Ando T, Yokata J. Acute fulminant myoglobinuric polymyositis with picornavirus-like crystals. J Neurol Neurosurg Psychiatr. 1977; 40:775-7. Google Scholar3. Davis WL, Jones RG, Farmer GR. Insect hemolymph factor promotes histolysis in Solenopsis. Anat Record. 1989; 224:473-8. Google Scholar4. Babior BR, Kipnes ZR, Curnutte J. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bacteriocidal agent. J Clin Invest. 1973; 52:741-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRhabdomyolysis Following Ad26.COV2.S COVID-19 VaccinationSuspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation TherapyA 3-year retrospective analysis of elderly patients with heat illnessCytomegalovirus myositis complicated with hemophagocytic lymphohistiocytosis, acute renal failure, and colitisVirus-associated Rhabdomyolysis in ChildrenSevere Fever with Thrombocytopenia Syndrome Presenting with RhabdomyolysisExperimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in GuineaRhabdomyolysis associated with cytomegalovirus infection in kidney transplant recipientsA rabdomiólise está associada à febre dengue em um paciente lúpicoRhabdomyolysis associated with dengue fever in a lupic patientCausality of rhabdomyolysis and combined tetanus, diphtheria and acellular pertussis (Tdap) vaccine administrationA case of a male presenting with fever, myalgia, leucopenia, thrombocytopenia and acute kidney injuryMeloxicam-Induced Rhabdomyolysis in the Context of an Acute Ross River Viral InfectionViral myositis leading to rhabdomyolysis: a case report and literature reviewVirus et musclesAcute encephalopathy and rhabdomyolysis following rotavirus gastroenteritisAn unusual cause of acute rhabdomyolysisRhabdomyolysis associated with acute renal failure in patients with severe acute respiratory syndromeRhabdomyolysis Associated with Dengue Virus InfectionTHE RELATIONSHIP OF INFECTIOUS AGENTS TO INFLAMMATORY MYOSITIS 15 October 1993Volume 119, Issue 8Page: 861-862KeywordsAttentionCreatine kinaseMyalgiaNecrosisPharyngitisRhabdomyolysisSerum glutamic oxaloacetic transaminaseSkeletal musclesTonsilsTumor necrosis factor Issue Published: 15 October 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
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Robert J. Konrad (1993) conducted a letter in Coxsackie B4 Rhabdomyolysis (n=1). Coxsackie B4 infection was evaluated. A 23-year-old man with Coxsackie B4 rhabdomyolysis presented with extreme creatine kinase elevation (650,000 U/L) and was treated with vigorous hydration and indomethacin.
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