Key result
Vitamin D insufficiency is linked to nearly doubled postoperative ICU admissions after elective non-cardiac surgery.
Why the study?
The relationship between vitamin D levels, frailty, and postoperative outcomes in geriatric patients undergoing elective surgery was not well established.
Does vitamin D insufficiency associate with frailty and worse postoperative outcomes in geriatric patients undergoing elective non-cardiac surgery?
Observational (n=90)
No
Does vitamin D insufficiency associate with frailty and worse postoperative outcomes in geriatric patients undergoing elective non-cardiac surgery?
Absolute Event Rate: 58.5% vs 30.6%
p-value: p=0.014
Vitamin D insufficiency is associated with higher frailty and increased postoperative ICU admission in geriatric patients undergoing non-cardiac surgery.
May link low vitamin D and frailty to worse postoperative outcomes in elderly non-cardiac surgery; leaves open whether supplementation alters risk in trials.
Objective: In this study, we aimed to investigate the relationship between vitamin D, frailty and postoperative outcomes in geriatric patients undergoing elective surgery. Methods: In this prospective observational study, a total of 90 elderly patients who had undergone non-cardiac surgery were included. The patients were classified according to the frailty index (FI) score as “Non-frail (FI 0), Pre-frail (FI 1–2) and Frail (FI ≥3)”. In addition, patients were divided into two groups according to serum vitamin D concentration: vitamin D insufficiency group (n=41) and vitamin D sufficiency group (n=49). Clinical characteristics and postoperative outcomes of the patients were compared between the groups. Results: The mean age of the patients was 75.7 ± 7.6 years, the admission rate to Intensive Care Unit (ICU) was 43.3%, and the 30-day mortality rate after surgery was 21.1%. The ICU admission was significantly higher in the “vitamin D insufficiency” group (n=24 versus n=15, p=0.014). In addition, fragility status patients were significantly higher in the “vitamin D insufficiency” group (n=19 versus n=7, p=0.004). Most of the non-frail patients were in the “vitamin D sufficiency” group (n=18 versus n=9). Conclusion: In our study, we observed higher frailty in vitamin D insufficiency patients. In addition, admission to the postoperative ICU was higher in vitamin D insufficiency and frail patients. Our findings show that frailty and vitamin D insufficiency play an important role in postoperative outcomes.
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Miniksar et al. (2023) conducted an observational in Geriatric patients undergoing elective non-cardiac surgery (n=90). Vitamin D insufficiency vs. Vitamin D sufficiency was evaluated on ICU admission (p=0.014). Vitamin D insufficiency in geriatric patients undergoing elective non-cardiac surgery was significantly associated with a higher rate of postoperative ICU admission compared to vitamin D sufficiency (58.5% vs 30.6%, p=0.014).
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