Key result
Five ACE gene SNPs show strong linkage disequilibrium across Arab and Asian populations.
Why the study?
DNA variations within the ACE gene are involved in the aetiology of several common diseases and therapeutic response, necessitating haplotype analysis in diverse populations.
Observational (n=100)
Yes
Answers are grounded in this paper and cite their sources.
Two key SNPs (rs1800764 and rs4340) in the ACE gene region were identified as valuable for future association studies in Arab and Asian populations.
BACKGROUND: DNA variations within the Angiotensin-Converting Enzyme (ACE) gene have been shown to be involved in the aetiology of several common diseases and the therapeutic response. METHODS: This study reports a comparison of haplotype analysis of five SNPs in the ACE gene region using a sample of 100 healthy subjects derived from five different populations (Tunisian, Iranian, Kuwaiti, Bahraini and Indian). RESULTS: Strong linkage disequilibrium was found among all SNPs studied for all populations. Two SNPs (rs1800764 and rs4340) were identified as key SNPs for all populations. CONCLUSIONS: These SNPs will be valuable for future effective association studies of the ACE gene polymorphisms in Arab and Asian populations.
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Kharrat et al. (2012) conducted an observational in Healthy (n=100). ACE gene polymorphisms (five SNPs) was evaluated on Linkage disequilibrium pattern. Five SNPs in the ACE gene region showed strong linkage disequilibrium across five Arab and Asian populations, with rs1800764 and rs4340 identified as key SNPs.
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