Why the study?
The association between oral glucocorticoid use and cardiovascular and cerebrovascular morbidity in patients over 50 years old was unclear.
Does oral glucocorticoid use increase the risk of cardiovascular or cerebrovascular events in patients over 50 years old?
Case-Control (n=101,312)
Does oral glucocorticoid use increase the risk of cardiovascular or cerebrovascular events in patients over 50 years old?
Odds Ratio: 1.25 (95% CI 1.21–1.29)
Oral glucocorticoid use is associated with an increased risk of cardiovascular and cerebrovascular events, particularly heart failure, though confounding by underlying disease activity cannot be fully excluded.
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B. Skaria (2004) conducted a case-control in Cardiovascular and cerebrovascular morbidity (n=101,312). Oral glucocorticoids vs. Non-users was evaluated on Cardiovascular or cerebrovascular events (OR 1.25, 95% CI 1.21-1.29).
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