Why the study?
Nicotine affects blood concentration and heart rate, but its acute effects on heart rate analyzed through Physiologically Based Toxico-Kinetics and Toxico-Dynamics modeling are not well characterized.
A compliance chamber designed for an artificial lung can maintain pulmonary artery pressure between 8 and 25 mm/Hg.
In modern world persons addicting to drugs are increasing gradually. Smoking, cocaine, nicotine etc. are harmful to human body. The most commonly affected organs are lung, liver, kidney. But the effect of nicotine is more in lungs which affect blood concentration and heart rate, analyzed using Physiologically Based Toxico-Kinetics and Physiologically Based Toxico-Dynamics modeling. The person affected by heart disease also has chance for lung failure. Best and safe method for avoiding lung failure is lung transplantation and fixing Artificial Lung (AL). In lung transplantation both the donor and recipient requirement should perfectly match, in Artificial Lung method any one of the lung assisting device is fixed instead of original lungs, but it is not analyzed effectively. In order to improve its efficiency the compliance chamber is designed and kept in between heart and lungs. By which the pulmonary artery pressure is maintained in the range between 8 to 25 mm/Hg.
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Helen et al. (2017) studied Nicotine effects on heart rate and artificial lung efficiency. Compliance chamber design for artificial lungs was evaluated on Pulmonary artery pressure.
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