Key result
Fluorescent in situ hybridization confirmed the diagnosis of primary extraosseous Ewing sarcoma of the brain in two patients by detecting FLI1 and/or EWS gene loci rearrangements.
Case Report (n=2)
Molecular analysis demonstrating t(11;22)(q24;q12) confirms the diagnosis of intracranial extraosseous Ewing sarcoma, distinguishing it from central PNET and guiding appropriate therapy.
The occurrence of primary extraosseous Ewing sarcoma (EES) of the central nervous system (CNS) has only rarely been reported in the literature. It is important to distinguish this entity from the more common central primitive neuroectodermal tumor (PNET) of brain, since the management of these tumors is different from that of EES. We present the clinical, radiologic, and pathologic features of two cases of EES occurring in the brain. The diagnosis was further confirmed by detection of a rearrangement of the FLI1 and/or EWS gene loci in tumors from both patients using fluorescent in situ hybridization (FISH). Although rare, the possibility of EES should be considered particularly when tumors that arise near the meningeal surface of the brain and have the pathologic appearance of a PNET. Demonstration of t(11;22)(q24;q12) by molecular analysis essentially confirms the diagnosis and enables the oncologist to choose appropriate therapy.
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Mazur et al. (2005) conducted a case report in Primary extraosseous Ewing sarcoma (EES) of the central nervous system (n=2). Fluorescent in situ hybridization (FISH) was evaluated on Diagnosis confirmation via detection of FLI1 and/or EWS gene loci rearrangement. Fluorescent in situ hybridization confirmed the diagnosis of primary extraosseous Ewing sarcoma of the brain in two patients by detecting FLI1 and/or EWS gene loci rearrangements.
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