Key result
Higher BMI rather than hyperandrogenism drives subclinical cardiovascular risk in PCOS, correlating strongly with epicardial fat.
Why the study?
It is unclear how much cardiovascular risk in PCOS is attributable to hyperandrogenism versus obesity, and ultrasound markers have been scarcely used in PCOS.
Cross-Sectional (n=102)
Single-blind
No
Effect estimate: r = 0.695
p-value: p=<0.001
In women with polycystic ovary syndrome, obesity rather than the hyperandrogenic phenotype is the primary driver of precocious ultrasound cardiovascular risk markers, particularly epicardial fat thickness.
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BMI assessment may refine early CV risk evaluation in PCOS over phenotype; hypothesis-generating and requires prospective validation.
Pandurevic et al. (2020) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) (n=102). Body mass index (BMI) vs. Normal weight vs overweight vs obese was evaluated on Correlation between BMI and epicardial fat thickness (EFT) (r = 0.695, p=<0.001). In women with polycystic ovary syndrome, body mass index rather than the hyperandrogenic phenotype was significantly associated with precocious ultrasound cardiovascular risk markers, with epicardial fat thickness showing the strongest correlation (r = 0.695, p < 0.001).
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