Review reveals mechanisms of cyclase-associated protein in developing neurons, highlighting its functional role in synapse morphogenesis and human brain disorders.
Studies of the past decade established cyclase-associated protein (CAP) as a key regulator of actin dynamics and associated its dysregulation with human brain disorders. However, its neuronal functions remained unknown until recent studies deciphered CAP-dependent mechanisms relevant for neuron differentiation or synapse morphogenesis, which are summarized and discussed in this forum article.
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Rust et al. (2025) studied this question.
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