Angiotensin converting enzyme 2 in patients with sepsis associate with comorbidities but neither with mortality nor with organ failure

Figures

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  Fig. 1. Kaplan–Meier curve of 28-day mortality in ACE2 is divided into quartiles. Quartile 1: < 2.66 ng/ml. Quartile 2: 2.66–4.64 ng/ml. Quartile 3: 4.64–9.31. Quartile 4: > 9.31 ng/ml. P value derived from log-rank test shows no significant pattern (p = 0.420). ACE2: angiotensin converting enzyme 2.

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  Fig. 2. ROC curves for biomarkers ACE2, CRP, creatinine and lactate corresponding to 28-day mortality. P-value derived from Dunn’s test comparing the area under ROC curves. ROC Receiver operating characteristics, ACE2 angiotensin converting enzyme 2; CRP C-reactive protein.

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  Fig. 3. Boxplots of ACE2 levels grouped into number of failing organs. No significant differences were seen when calculated with pairwise Wilcoxon test. ACE2 angiotensin converting enzyme 2.

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  Fig. 4. Boxplots of ACE2 levels grouped after patient referral from the emergency department. P-values derived from pairwise Wilcoxon test. *P < 0.05, **P < 0.01. No significance remained after adjustment for age, body mass index, cardiovascular disease, respiratory disease, upper respiratory tract and urinary site of infection, in a multivariate logistic regression (ward: P = 0.53, IMCU: P = 0.14, ICU: P = 0.90). ACE2 angiotensin converting enzyme 2; IMCU intermediate care unit; ICU intensive care unit.