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January 1, 2022Biomarker InsightsOpen Access

Elevated serum ACE2 levels in COVID-19 patients were significantly associated with ICU admission (P=0.0007) and death (P=0.0082).

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Why the study?

Are elevated serum ACE2 levels associated with increased disease severity and worse clinical outcomes in patients with COVID-19?

Population

267 subjects, including 144 COVID-19-positive patients and 123 COVID-19-negative healthy controls.

Comparison

Measurement of serum ACE2 levels at hospital… vs COVID-19-negative healthy controls, and…

Design

Cross-sectional

Key result

Elevated serum ACE2 levels in COVID-19 patients were significantly associated with ICU admission (P=0.0007) and death (P=0.0082).

Authors

AHAmjad Bani HaniUniversity of JordanNTNafez Abu TarboushUniversity of JordanMAMo’ath Bani AliTechnology Innovation Institute

Discussion

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Member takes

Overview

Elevated ACE2 signals higher ICU and mortality risk in COVID-19; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Cross-Sectional (n=267)

Structured PICO

Are elevated serum ACE2 levels associated with increased disease severity and worse clinical outcomes in patients with COVID-19?

P
Population
267 subjects, including 144 COVID-19 patients and 123 healthy controls, evaluated for the association between serum ACE2 levels and COVID-19 severity.
E
Exposure
Measurement of serum ACE2 levels at hospital admission.
C
Comparator
COVID-19-negative healthy controls, and comparisons among COVID-19 patient subgroups based on disease severity.
O
Outcome
Association between circulating ACE2 levels and clinical outcomes (severity of COVID-19, ICU admission, death, and length of stay).surrogate

Main Result

p-value: p=0.0007

Elevated serum ACE2 levels at hospital admission are associated with increased disease severity, ICU admission, and mortality in patients with COVID-19.

Cite This Study

Hani et al. (2022) conducted a cross-sectional in COVID-19 (n=267). Serum ACE2 levels vs. Healthy controls / lower ACE2 levels was evaluated on ICU admission and Death (p=0.0007). Elevated serum ACE2 levels in COVID-19 patients were significantly associated with ICU admission (P=0.0007) and death (P=0.0082).

synapsesocial.com/papers/6ab64240bb3fdd31b74493f6https://doi.org/10.1177/11772719221125123
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1#2395 Elevated circulating ACE2 activity is related with a major COVID-19 severity2024
  2. 2Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients2021 · 104 citations
  3. 3Correlation between serum Angiotensin II level and severity of COVID-19 disease2026
  4. 4The Role of Soluble ACE2 as a Prognostic Marker in Severe COVID-19: A Brief Meta-Analysis2022 · 5 citations
  5. 5Plasma ACE and ACE2 Levels Are Altered in Patients with COVID-192026