Key result
Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors compared to healthy controls.
Case-Control (n=96)
Both early- and late-onset preeclampsia are characterized by increased systemic vascular resistance and elevated levels of endogenous nitric oxide synthesis inhibitors.
Supports endothelial-targeted approaches in preeclampsia; hypothesis-generating and should not change practice without prospective validation.
OBJECTIVE: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. METHODS: Twenty-four preeclamptic patients (14 at ≥ 34 weeks') and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. ADMA and SDMA levels were determined using enzyme-linked immunosorbent assay. RESULTS: SVRI and SDMA were higher in preeclampsia overall, in early onset and late onset compared to controls. SVRI was correlated with ADMA and SDMA, respectively. CONCLUSIONS: Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors.
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Lučovnik et al. (2017) conducted a case-control in Preeclampsia (n=96). Preeclampsia vs. Matched healthy controls was evaluated on Systemic vascular resistance index (SVRI), ADMA, and SDMA levels. Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors compared to healthy controls.
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