Association of aortic dilation with regurgitant, stenotic and functionally normal bicuspid aortic valves
Key result
Bicuspid aortic valve links to larger aortic root size vs controls irrespective of altered hemodynamics.
- P<0.05 to <0.001
- n=83
Why the study?
It was uncertain whether aortic root dilation associated with bicuspid aortic valve occurs independently of valvular hemodynamic abnormalities.
Population
83 adults with bicuspid aortic valve and matched normal subjects
Comparison
Functionally normal, mildly regurgitant, severely regurgitant, and stenotic bicuspid aortic valves versus normal subjects
Design
Two-dimensional echocardiographic measurement study
Authors
Discussion
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Implication
Observational study reveals aortic dilation across diverse bicuspid aortic valve phenotypes, indicating that vessel enlargement occurs independent of valvular dysfunction.
Key Points
- To examine the frequency and severity of aortic dilation across bicuspid aortic valve presentations, comparing regurgitant, stenotic, and functionally normal valves.
- Categorized patient cohorts with bicuspid aortic valves according to functional status: regurgitant, stenotic, or functionally normal.
- Measured aortic diameters at the sinus of Valsalva and ascending aorta using clinical cardiovascular imaging.
- Ascending aortic dilation occurs across all functional subsets of bicuspid aortic valves, with substantial prevalence even in functionally normal valves.
- Aortic root and ascending aorta enlargement rates and dimensions vary by hemodynamic profile, but valvular dysfunction is not required for significant aortopathy.
Study Design
Type
Case-Control (n=83)
PICO
P
Population
83 adults with bicuspid aortic valves of varying hemodynamic severity compared to age- and gender-matched normal subjects.
E
Exposure / Comparator
Bicuspid aortic valve vs Normal subjects matched for age and gender
O
Primary Outcome
Aortic root size at four levels (anulus, sinuses of Valsalva, supraaortic ridge, proximal ascending aorta), p=<0.05 to <0.001
Main Result
p-value: p=<0.05 to <0.001
Cite This Study
Hahn et al. (1992) conducted a case-control in Bicuspid aortic valve (n=83). Bicuspid aortic valve vs. Normal subjects matched for age and gender was evaluated on Aortic root size at four levels (anulus, sinuses of Valsalva, supraaortic ridge, proximal ascending aorta) (p=<0.05 to <0.001). Bicuspid aortic valve was associated with significantly larger aortic root size at three levels compared to matched controls (p<0.05 to p<0.001), irrespective of altered hemodynamics.