Key result
Higher radiation doses (7 and 14 Gy) significantly reduced doxorubicin tissue penetration depth after PIPAC in an ex-vivo model (e.g., 284 ± 57 µm for 14 Gy vs 476 ± 74 µm for control at 15 min; p<0.001).
Why the study?
Does irradiation affect the tissue penetration depth of doxorubicin delivered via PIPAC in an ex-vivo swine peritoneum model?
Population
Fresh post mortem swine peritoneum cut into 10 proportional sections
Comparison
Irradiation followed by Pressurized… vs Control samples receiving PIPAC with doxorubicin…
Design
Preclinical
Authors
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High-dose irradiation may reduce doxorubicin penetration after PIPAC in ex-vivo tissue; hypothesis-generating and requires in-vivo validation before clinical consideration.
Does irradiation affect the tissue penetration depth of doxorubicin delivered via PIPAC in an ex-vivo swine peritoneum model?
p-value: p=<0.001
Higher fractional radiation doses (7 and 14 Gy) reduce the tissue penetration depth of doxorubicin delivered via PIPAC in an ex-vivo swine model, whereas lower doses (1 and 2 Gy) do not.
Khosrawipour et al. (2016) studied this question. Irradiation prior to Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) vs. No irradiation (control) was evaluated on In-tissue doxorubicin penetration depth (µm) (p=<0.001). Higher radiation doses (7 and 14 Gy) significantly reduced doxorubicin tissue penetration depth after PIPAC in an ex-vivo model (e.g., 284 ± 57 µm for 14 Gy vs 476 ± 74 µm for control at 15 min; p<0.001).
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