Key result
Intra-abdominal pressure of 20 and 30 mm Hg significantly decreased AUC ratios of i.p. doxorubicin but increased tissue uptake in the bladder, diaphragm, and abdominal wall during the first 10 min.
Why the study?
Does increased intra-abdominal pressure improve the pharmacokinetics and tissue distribution of intraperitoneal doxorubicin in Sprague Dawley rats?
Population
60 Sprague Dawley rats
Comparison
Intraperitoneal doxorubicin combined with… vs Intraperitoneal doxorubicin combined with no…
Design
Preclinical
Follow-up
10 or 60 minutes
Authors
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Raises ischemia caution with sustained pressure; hypothesis-generating for pressure-optimized IP doxorubicin delivery in peritoneal disease.
Does increased intra-abdominal pressure improve the pharmacokinetics and tissue distribution of intraperitoneal doxorubicin in Sprague Dawley rats?
Increased intra-abdominal pressure during intraperitoneal chemotherapy administration enhances early tissue uptake of doxorubicin but may cause intestinal ischemia if prolonged.
Jacquet et al. (1996) studied Pharmacokinetics of intraperitoneal doxorubicin (n=60). Increased intra-abdominal pressure vs. No pressure (control) was evaluated on Pharmacokinetics (AUCs) and tissue distribution of doxorubicin. Intra-abdominal pressure of 20 and 30 mm Hg significantly decreased AUC ratios of i.p. doxorubicin but increased tissue uptake in the bladder, diaphragm, and abdominal wall during the first 10 min.
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