Why the study?
Does subatmospheric pressure prevent doxorubicin extravasation ulcers in a swine model?
Population
4 pigs, with 8 sites injected intradermally with doxorubicin on each pig (total 32 sites)
Comparison
125 mm Hg subatmospheric pressure applied 1 h… vs Untreated control sites
Design
Preclinical
Follow-up
5 weeks
Authors
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Hypothesis-generating for subatmospheric pressure in doxorubicin extravasation; prospective human trials needed before clinical adoption.
Does subatmospheric pressure prevent doxorubicin extravasation ulcers in a swine model?
Application of subatmospheric pressure significantly prevented the formation of doxorubicin extravasation ulcers in a swine model.
Morykwas et al. (1999) studied this question.
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