Key result
Femoral stenosis resistance combines a fixed component with flow-dependent variable resistance across ~68-94% area reductions.
Why the study?
An accurate model of the pressure-flow relationship of femoral artery stenoses is necessary for correct interpretation of haemodynamic measurements.
In vitro modeling demonstrates that the resistance of a significant femoral artery stenosis is not fixed but increases linearly with flow, dominating at physiological flow rates.
Challenges fixed-resistance models of femoral stenoses; leaves open whether flow dependence refines physiologic severity assessment in peripheral artery disease.
An accurate model of the pressure-flow relationship of a stenosis is necessary for the correct interpretation of haemodynamic measurements. Modelled femoral artery stenoses were tested in vitro and the pressure drop: flow ratio (resistance) was most accurately represented by a fixed component (Rf) combined with a variable component (Rv) that increased linearly with flow (Q) such that Rv = SvQ. For stenoses of 68-94 per cent area, Rf increased from 3.2 to 77.7 milliperipheral resistance units (mPRU), while Sv increased from 0.009 to 0.578 mPRU ml-1 min and Rv was dominant for physiological flow rates. It was concluded that the approximation of a significant stenosis to a fixed resistance is incorrect.
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Dodds et al. (1996) studied Femoral artery stenosis. Modelled femoral artery stenoses was evaluated on Pressure drop: flow ratio (resistance). For modelled femoral artery stenoses of 68-94% area, resistance was most accurately represented by a fixed component combined with a variable component that increased linearly with flow.
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