Key result
Moderate NAFLD is linked to increased carotid inflammation, particularly in older men.
Why the study?
The association between nonalcoholic fatty liver disease and carotid artery inflammation measured by FDG PET/CT in healthy adult males was unclear.
Is nonalcoholic fatty liver disease associated with increased carotid artery inflammation in otherwise healthy adult males?
Cross-Sectional (n=755)
Is nonalcoholic fatty liver disease associated with increased carotid artery inflammation in otherwise healthy adult males?
Absolute Event Rate: 1.63% vs 1.58%
p-value: p=.005
In otherwise healthy adult males, NAFLD is associated with increased carotid artery inflammation on 18F-FDG PET/CT, suggesting an elevated risk for inflammatory atherosclerotic plaques.
We assessed the association between nonalcoholic fatty liver disease (NAFLD) and carotid artery inflammation measured by (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. Participants were 755 consecutive otherwise healthy adult males who underwent a general health screening program. Carotid FDG uptake, represented as maximum target-to-background ratio, was increased with mild (n = 237; 1.61 ± 0.14; P = .033) and moderate NAFLD (n = 145; 1.63 ± 0.16; P = .005) compared with controls (n = 373; 1.58 ± 0.15). In patients aged >50 years, moderate NAFLD was the only independent risk factor for high carotid FDG uptake (odds ratio, 2.12; 95% confidence interval, 1.10-4.07; P = .001). Apparently healthy adult males with NAFLD have elevated carotid FDG uptake as well as increased carotid intima-media thickness, suggesting that they may be at an increased risk of having inflammatory atherosclerotic plaques in the carotid arteries.
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Moon et al. (2014) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=755). Nonalcoholic fatty liver disease (NAFLD) vs. Controls (no NAFLD) was evaluated on Carotid FDG uptake (maximum target-to-background ratio) (p=.005). Moderate nonalcoholic fatty liver disease was associated with increased carotid FDG uptake compared to controls (1.63 vs 1.58; P=.005) and was an independent risk factor for high uptake in men >50.
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