Key result
Elevated aldosterone and aldosterone-renin ratio are linked to increased carotid intima-media thickness in hypertension.
Why the study?
Is carotid intima-media thickness increased in hypertensive patients with a high aldosterone/plasma renin activity ratio and elevated aldosterone plasma concentration?
Is carotid intima-media thickness increased in hypertensive patients with a high aldosterone/plasma renin activity ratio and elevated aldosterone plasma concentration?
Hypertensive patients with high aldosterone/plasma renin activity ratio and elevated aldosterone may have increased carotid intima-media thickness.
Hypothesis-generating in a single-center observational cohort; leaves open whether findings warrant prospective validation before practice change.
aNeurology Department, Spain bClinical and Experimental Vascular Risk Unit, University Hospital Virgen del Rocio, Seville, Spain Correspondence to Professor Dr Pablo Stiefel, MD, PhD, Unidad Clínico Experimental de riesgo Vascular (UCERV), University Hospital Virgen del Rocio, Avda Manuel Siurot s/n, 41013 Seville, Spain Tel: +34 955012266; e-mail: [email protected]
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González-Pérez et al. (2008) studied this question. A high aldosterone/plasma renin activity ratio and elevated aldosterone plasma concentration are associated with increased carotid intima-media thickness in hypertensive patients.
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