Key result
Primary aldosteronism was associated with greater carotid intima-media thickness (0.84 vs 0.69 mm, P<0.01) and femoral pulse wave velocity (10.8 vs 9.1 m/s, P<0.03) than essential hypertension.
Why the study?
Does primary aldosteronism increase arterial stiffness and carotid artery fibrosis compared to essential hypertension and healthy controls?
Population
62 subjects, including 23 consecutive patients with primary aldosteronism, 24 matched patients with…
Comparison
Primary aldosteronism (exposure) vs Essential hypertension and healthy controls
Design
Cross-sectional
Authors
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Suggests heightened vascular risk in primary aldosteronism; leaves open whether screening or therapy modifies stiffness or outcomes.
Observational (n=62)
No
Does primary aldosteronism increase arterial stiffness and carotid artery fibrosis compared to essential hypertension and healthy controls?
Absolute Event Rate: 0.84% vs 0.59%
p-value: p=<0.0001
Aldosterone excess in primary aldosteronism is associated with significantly greater vascular wall thickening, carotid artery fibrosis, and central arterial stiffness compared to essential hypertension.
Bernini et al. (2008) conducted an observational in Primary aldosteronism (n=62). Primary aldosteronism vs. Essential hypertension and controls was evaluated on Intima-media thickness (p=<0.0001). Primary aldosteronism was associated with greater carotid intima-media thickness (0.84 vs 0.69 mm, P<0.01) and femoral pulse wave velocity (10.8 vs 9.1 m/s, P<0.03) than essential hypertension.
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