Why the study?
Does primary aldosteronism increase extracellular matrix fibrosis in small resistance arteries compared to essential hypertension?
Population
13 patients with primary aldosteronism, 7 patients with essential hypertension, and 10 normotensive controls
Comparison
Primary aldosteronism (disease state) vs Essential hypertension and normotensive controls
Design
Cross-sectional
Authors
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Primary aldosteronism was associated with greater microvascular fibrosis; leaves open whether this warrants aldosterone-specific interventions.
Does primary aldosteronism increase extracellular matrix fibrosis in small resistance arteries compared to essential hypertension?
Primary aldosteronism is associated with more pronounced fibrosis in small resistance arteries compared to blood-pressure-matched essential hypertension, suggesting a direct profibrotic effect of aldosterone in human microcirculation.
Rizzoni et al. (2006) studied this question.
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