What question did this study set out to answer?

To determine whether endothelial dysfunction in small resistance arteries relates to specific causes of hypertension, structural vascular remodeling, or blood pressure levels.

January 1, 1998HypertensionOpen Access

Endothelial Dysfunction in Hypertension Is Independent From the Etiology and From Vascular Structure

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Population

60 subjects including 49 patients with hypertension and 11 normotensive controls

Design

Cross-sectional

Authors

DRDamiano RizzoniGeneral Cardiology EPEnzo PorteriUniversity of Brescia MCMaurizio CastellanoUniversity of Pisa

Discussion

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Implication

Ambulatory BP load was associated with endothelial dysfunction independent of hypertension etiology or remodeling; hypothesis-generating for prospective validation.

Key Points

To determine whether endothelial dysfunction in small resistance arteries relates to specific causes of hypertension, structural vascular remodeling, or blood pressure levels.
Evaluated 60 participants: 9 with pheochromocytoma, 10 with primary aldosteronism, 17 with renovascular hypertension, 13 with essential hypertension, and 11 normotensive controls.
Harvested small resistance arteries from subcutaneous fat biopsies, mounted them on a micromyograph to determine the media/lumen ratio, and tested cumulative acetylcholine vasodilation (10⁻⁹ to 10⁻⁵ mol/L).
Measured clinic blood pressure and 24-hour ambulatory blood pressure monitoring (ABPM) in all subjects.
Vasodilator response to acetylcholine was similarly blunted across all four hypertensive cohorts compared to normotensive controls (ANOVA P < .05), with no differences observed between hypertensive etiologies.
Media/lumen ratio was significantly increased in primary aldosteronism and renovascular hypertension, but structural remodeling did not correlate with maximum acetylcholine-induced vasodilation.
Maximum acetylcholine-induced vasodilation correlated significantly with 24-hour ABPM (systolic r = 0.34, P < .05; diastolic r = 0.36, P < .05), while showing no correlation with clinic blood pressure.

Structured PICO

Population

60 subjects including 49 patients with hypertension (9 with pheochromocytoma, 10 with primary aldosteronism, 17 with renovascular hypertension, 13 with essential hypertension) and 11 normotensive controls

Comparator

Normotensive controls

Outcome

Vasodilator response to acetylcholine and media/lumen ratio of small resistance arteriessurrogate

Endothelial dysfunction in hypertension is linked to hemodynamic load (ambulatory blood pressure) rather than the specific etiology of hypertension or the degree of vascular structural alterations.

Cite This Study

Rizzoni et al. (1998) studied this question.

synapsesocial.com/papers/6a6fc13fac440176ef286a83 https://doi.org/10.1161/01.hyp.31.1.335

Topics

Hypertension management

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Implication

Ambulatory BP load was associated with endothelial dysfunction independent of hypertension etiology or remodeling; hypothesis-generating for prospective validation.

Endothelial Dysfunction in Hypertension Is Independent From the Etiology and From Vascular Structure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Endothelial Dysfunction in Hypertension Is Independent From the Etiology and From Vascular Structure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider