Key result
Essential hypertension was associated with significantly higher von Willebrand factor levels compared to healthy controls (114 vs 90 IU/dl, p=0.04), but no convincing differences in endothelial dysfunction markers were found between endocrine and essential hypertension.
Cross-Sectional (n=100)
No
Endothelial dysfunction markers do not significantly differ between essential and endocrine hypertension, suggesting that prolonged overproduction of vasopressor substances does not lead to more severe endothelial dysfunction.
Answers are grounded in this paper and cite their sources.
Endothelial markers appear comparable across hypertension subtypes; leaves open whether vWF elevation marks distinct pathophysiology in essential hypertension.
The aim of our study was to evaluate potential differences in the concentration of biochemical markers of endothelial dysfunction between essential hypertension, endocrine hypertension (pheochromocytoma, primary hyperaldosteronism) and control healthy group and to assess a potential relationship between these markers of endothelial dysfunction and vasopressor substances overproduced in endocrine hypertension. We have investigated 21 patients with moderate essential hypertension, 29 patients with primary hyperaldosteronism, 24 subjects with pheochromocytoma and 26 healthy volunteers. Following parameters of endothelial dysfunction were measured, von Willebrand factor (vWf), plasminogen activator (t-PA) and E-selectin (E-sel). Clinical blood pressure was measured according to the European Society of Hypertension recommendations. We found significantly higher levels of the von Willebrand factor in patients with essential hypertension in comparison with a control group (114+/-20 IU/dl vs 90+/-47 IU/dl; P=0.04) and patients with primary hyperaldosteronism (114+/-20 IU/dl vs 99+/-11 IU/dl; P=0.01). Patients with endocrine hypertension revealed increased levels of vWF compared to the control group, but these differences did not reach statistical significance. Levels of t-PA were increased in patients with pheochromocytoma in comparison with the control group (4.6+/-1.9 ng/ml vs 3.4+/-0.9 ng/ml; P=0.01) and with primary hyperaldosteronism (4.6+/-1.9 ng/ml vs 3.4+/-1.1 ng/ml; P<0.01). In case of E-selectin we found lower levels in patients with pheochromocytoma in comparison with other groups, but they differed significantly only with primary hyperaldosteronism (40.2+/-15.0 ng/ml vs 51.3+/-23.0 ng/ml; P=0.05). Our study did not reveal any convincing evidence of differences in the levels of biochemical markers of endothelial dysfunction between essential and endocrine hypertension. No correlation between the biochemical markers of endothelial dysfunction and vasopressor substances activated in endocrine hypertension was found.
No takes yet. Share an insight, caveat, or question.
Petrák et al. (2006) conducted a cross-sectional in Essential and endocrine hypertension (primary hyperaldosteronism, pheochromocytoma) (n=100). Essential hypertension vs. Healthy controls was evaluated on von Willebrand factor (vWF) levels (p=0.04). Essential hypertension was associated with significantly higher von Willebrand factor levels compared to healthy controls (114 vs 90 IU/dl, p=0.04), but no convincing differences in endothelial dysfunction markers were found between endocrine and essential hypertension.
Synapse has enriched 10 related papers. Consider them for comparative context: