Key result
Patients with essential hypertension had significantly higher plasma levels of vasoactive peptides compared to healthy controls (3.28 vs. 1.80 pmol/L; p<0.01), correlating with disease severity.
Why the study?
Are plasma levels of urotensin II, endothelin, and adrenomedullin associated with essential hypertension and its severity?
Case-Control (n=160)
Are plasma levels of urotensin II, endothelin, and adrenomedullin associated with essential hypertension and its severity?
Absolute Event Rate: 3.28% vs 1.8%
p-value: p=<0.01
Vasoactive peptides urotensin II, endothelin, and adrenomedullin are elevated in essential hypertension and correlate with disease severity and left ventricular structural changes.
AIM: The aim of the study is to measure the vasoactive peptides, urotensin II (UII), endothelin (ET) and adrenomedullin (ADM) in a well-characterized population of normal controls and patients with essential hypertension, and to study their association with this disease. METHODS: The contents of plasma UII, ET and ADM were measured by radioimmunoassay in 40 normal controls and 120 patients with essential hypertension. Echocardiographic examinations were performed using an ultrasonic system, and the left ventricular end diastolic diameter (LVEDd) along with the left ventricular posterior wall thickness (LVPWT) and interventricular septal thickness (IST) were determined. The left ventricular mass index (LVMI) was calculated according to the method reported by Devereux et al. RESULTS: Plasma UII, ET and ADM contents were increased in patients than healthy controls (3.28 ± 1.257 pmol/L vs. 1.80 ± 0.639 pmol/L, p < 0.01), and correlated with the severity of hypertension in patients. Besides, all the three vasoactive peptides in plasma had significant correlations with SBP, IST, LVPWT, LVMI (p ≤ 0.05), while they showed insignificant associations with LVEDd (p > 0.05). UII was remarkably associated with ADM content, while the association of UII level with LVEDd and ET content were not significant. CONCLUSION: The vasoactive peptides UII, ET and ADM may be involved in the pathophysiologic process of essential hypertension, and function as the indicators for severity of this disease.
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Sui et al. (2015) conducted a case-control in Essential hypertension (n=160). Essential hypertension vs. Healthy controls was evaluated on Plasma UII, ET and ADM contents (p=<0.01). Patients with essential hypertension had significantly higher plasma levels of vasoactive peptides compared to healthy controls (3.28 vs. 1.80 pmol/L; p<0.01), correlating with disease severity.
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