Key result
PM/DM is linked to higher myocardial native T1 and expanded extracellular volume vs healthy controls.
Why the study?
Polymyositis and dermatomyositis patients are prone to adverse cardiovascular events, but early myocardial involvement detection methods are needed.
Does cardiac MRI with T1 mapping detect subclinical myocardial involvement in asymptomatic patients with polymyositis or dermatomyositis compared to healthy controls?
Observational (n=50)
Does cardiac MRI with T1 mapping detect subclinical myocardial involvement in asymptomatic patients with polymyositis or dermatomyositis compared to healthy controls?
Cardiac MRI with T1 mapping and extracellular volume quantification can detect subclinical myocardial involvement in asymptomatic patients with polymyositis and dermatomyositis.
Answers are grounded in this paper and cite their sources.
May identify subclinical myocardial involvement in PM/DM via T1 mapping; leaves open prognostic value and need for outcome trials.
Background Polymyositis (PM) and dermatomyositis (DM) are common types of idiopathic inflammatory myopathy (IIM), wherein patients are prone to adverse cardiovascular events. Purpose To explore the value of cardiac magnetic resonance imaging (MRI) for detecting cardiac involvement in PM/DM patients using a T1 mapping technique. Study Type Prospective observational study. Population In all, 25 PM/DM patients free of cardiovascular symptoms and preserved ventricular systolic function and 25 healthy volunteers matched for age and sex served as controls. Field Strength/Sequence Cardiac MRI at 3T, including steady‐state free precession (SSFP) cine imaging, late gadolinium enhancement (LGE), and T1 mapping with modified Look–Locker inversion recovery (MOLLI). Assessment Myocardial native T1 and extracellular volume (ECV) of the left ventricle as well as the correlations with disease activity were analyzed. Statistical Tests Independent sample's t‐test, Fisher's exact test, or chi‐square test, Pearson's correlation (r) were applied. P ≤ 0.05 was considered significant. Results Left ventricular end‐diastolic/end‐systolic volume index (P = 0.643, P = 0.325, respectively), mass index (P = 0.719), and ejection fraction (P = 0.144) were not significantly different between PM/DM patients and controls. LGE was found in 19% of PM/DM patients and none of the control subjects. PM/DM patients showed significantly higher native T1 values (1263.7 ± 84.0 msec vs. 1200.6 ± 43.0 msec, P = 0.002) and expanded extracellular volume (ECV) (32.6 ± 3.7% vs. 26.7 ± 2.3%, P < 0.001) compared with control subjects. ECV values in PM/DM patients had a high proportion (60%) over the 95% percentile of normal controls. Meanwhile, there was a significant correlation between native T1 (r = 0.710, P = 0.0001) or ECV (r = 0.508, P = 0.01) and N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP). Data Conclusion T1 mapping of cardiac MRI is valuable to detect subclinical myocardial involvement in PM/DM patients, and both myocardial native T1 and ECV could serve as early imaging markers for myocardial impairment in PM/DM. Level of Evidence: 2 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2018;48:415–422.
No takes yet. Share an insight, caveat, or question.
Yu et al. (2018) conducted an observational in Polymyositis and dermatomyositis (n=50). Polymyositis and dermatomyositis vs. Healthy volunteers was evaluated on Myocardial native T1 (msec) (p=0.002). PM/DM patients showed higher myocardial native T1 values and expanded extracellular volume compared with healthy controls.
Synapse has enriched 10 related papers. Consider them for comparative context: