Key result
Excluding subjects with levels >10 ng/mL, serum vaspin levels were significantly decreased in systemic sclerosis patients with digital ulcers compared with those without.
Why the study?
Do serum vaspin levels correlate with the presence of digital ulcers in patients with systemic sclerosis?
Observational
Do serum vaspin levels correlate with the presence of digital ulcers in patients with systemic sclerosis?
Decreased serum vaspin levels are associated with digital ulcers in systemic sclerosis, suggesting a potential role in vascular complications of the disease.
May stratify digital ulcer risk in SSc; hypothesis-generating for vaspin as vasculopathy biomarker, needs prospective validation.
Vaspin is an adipokine implicated in vascular inflammation and remodeling. We herein evaluated the clinical correlation of serum vaspin levels in systemic sclerosis (SSc). Consistent with previous reports, 12% of subjects exhibited serum vaspin levels over 10 ng/mL, likely due to genetic effects. Excluding these subjects, despite no difference between SSc and control subjects, serum vaspin levels were significantly decreased in SSc patients with digital ulcers compared with those without, suggesting the potential contribution of vaspin to digital ulcers of this disease.
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Miura et al. (2015) conducted an observational in Systemic sclerosis. Serum vaspin levels vs. Patients without digital ulcers and control subjects was evaluated on Presence of digital ulcers. Excluding subjects with levels >10 ng/mL, serum vaspin levels were significantly decreased in systemic sclerosis patients with digital ulcers compared with those without.
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