Key result
Peritoneal dialysis and hemodialysis both impacted spontaneous brain activity differently in end-stage renal disease patients compared to healthy controls, with significant regional alterations.
Why the study?
Does peritoneal dialysis compared to hemodialysis affect spontaneous brain activity differently in patients with end-stage renal disease?
Cross-Sectional (n=101)
Does peritoneal dialysis compared to hemodialysis affect spontaneous brain activity differently in patients with end-stage renal disease?
Peritoneal dialysis and hemodialysis manifest different impacts on spontaneous brain activity in patients with end-stage renal disease.
May suggest dialysis modality differences in ESRD brain activity; leaves open optimal choice for cognition pending prospective data.
OBJECTIVE: To compare the effects of peritoneal dialysis and hemodialysis on spontaneous brain activity in patients with end-stage renal disease. METHODS: A total of 52 dialysis patients with end-stage renal disease, including 25 patients with chronic kidney disease undergoing hemodialysis (HD-CKD) and 27 patients with chronic kidney disease undergoing peritoneal dialysis (PD-CKD), and 49 healthy controls (normal control) were included. All participants underwent neuropsychological testing (Mini-Mental State Examination and Montreal cognitive assessment) and resting-state functional magnetic resonance imaging. Fractional amplitude of low frequency fluctuations and Regional Homogeneity algorithms were employed to evaluate spontaneous brain activity. Statistical analysis was performed to discern differences between the groups. RESULTS: When compared with the normal control group, the PD-CKD group exhibited significant alterations in fractional amplitude of low frequency fluctuations in various cerebellum regions and other brain areas, while the HD-CKD group showed decreased fractional amplitude of low frequency fluctuations in the bilateral pericalcarine cortex. The Regional Homogeneity values in the PD-CKD group were notably different than those in the normal control group, particularly in regions such as the bilateral caudate nucleus and the right putamen. CONCLUSION: Both peritoneal dialysis and hemodialysis modalities impact brain activity, but manifest differently in end-stage renal disease patients. Understanding these differences is crucial for optimizing patient care.
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Zhang et al. (2023) conducted a cross-sectional in end-stage renal disease (n=101). Peritoneal dialysis and hemodialysis vs. Healthy controls was evaluated on Spontaneous brain activity evaluated by fractional amplitude of low frequency fluctuations and Regional Homogeneity. Peritoneal dialysis and hemodialysis both impacted spontaneous brain activity differently in end-stage renal disease patients compared to healthy controls, with significant regional alterations.
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