Racial and ethnic differences in subclinical myocardial function: the Multi-Ethnic Study of Atherosclerosis
Key result
Chinese-American ethnicity is linked to significantly higher peak systolic strain than other racial groups.
- P<0.05
- n=1,099
Why the study?
Racial and ethnic differences in the incidence and severity of heart failure are not well understood and may relate to variations in myocardial function.
Population
1099 asymptomatic individuals without baseline cardiovascular disease from four major racial/ethnic groups
Comparison
Racial/ethnic differences in regional myocardial function
Design
Prospective observational study within the Multi-Ethnic Study of Atherosclerosis
Authors
Discussion
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Implication
Race differences in LV strain may underlie HF disparities; hypothesis-generating and requires prospective validation before clinical use.
Study Design
Type
Observational (n=1,099)
Multicenter
Yes
Structured PICO
P
Population
1,099 asymptomatic individuals free of known cardiovascular disease representing four major racial/ethnic groups.
E
Exposure
Race/ethnicity (Chinese-American, African-American, Hispanic, and other groups)
C
Comparator
Comparison between different racial/ethnic groups
O
Outcome
Peak systolic strain (Ecc) and strain rate (SRs) in four left ventricular regions determined by cardiac MRI with tissue taggingsurrogate
Main Result
p-value: p=<0.05
There are significant race-based differences in regional left ventricular systolic function among asymptomatic individuals without cardiovascular disease, which may contribute to disparities in heart failure incidence and severity.
Cite This Study
Fernandes et al. (2011) conducted an observational in Asymptomatic, free of known cardiovascular disease (n=1,099). Race/ethnicity vs. Other racial/ethnic groups was evaluated on Regional myocardial function (peak systolic strain [Ecc] and strain rate [SRs]) (p=<0.05). Significant race-based differences in regional LV systolic function exist, with Chinese-Americans having the greatest magnitude of peak systolic strain (-19.60±3.78; p<0.05).