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August 24, 2019Open Access

A D-dimer cutoff value of 4.8 μg/mL demonstrated 100% sensitivity and 85% specificity for detecting deep venous thrombosis in pregnant women with threatened premature delivery and abortion.

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Why the study?

Does D-dimer testing accurately detect DVT in pregnant women with threatened premature delivery and abortion?

Population

335 singleton pregnant women hospitalized for longer than 4 days due to threatened premature delivery and…

Design

Cohort

Follow-up

from hospitalization to delivery

Key result

A D-dimer cutoff value of 4.8 μg/mL demonstrated 100% sensitivity and 85% specificity for detecting deep venous thrombosis in pregnant women with threatened premature delivery and abortion.

Authors

HKHaruka KawauchiMMMorikazu MiyamotoTSTakahiro Sakamoto

Discussion

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Overview

D-dimer thresholds for DVT in high-risk pregnancy need validation; leaves open optimal cutoffs for clinical use.

Study Design

Type

Observational (n=335)

Multicenter

No

Structured PICO

Does D-dimer testing accurately detect DVT in pregnant women with threatened premature delivery and abortion?

P
Population
335 singleton pregnant women hospitalized for more than 4 days due to threatened premature delivery and abortion, evaluated for deep venous thrombosis using D-dimer levels.
E
Exposure
D-dimer testing (measured at least once per week from hospitalization to delivery)
O
Outcome
Normal range of D-dimer levels and cutoff value to detect DVTsurrogate

Main Result

Effect estimate: Sensitivity 100%, Specificity 85%

A D-dimer cutoff of 4.8 μg/mL provides high sensitivity and specificity for detecting DVT in pregnant women hospitalized for threatened premature delivery and abortion.

Limitations

  • Single-institutional study
  • Retrospective analysis
  • Very few pregnant women with DVT

Cite This Study

Kawauchi et al. (2019) conducted an observational in Threatened premature delivery and abortion (n=335). D-dimer test (cutoff 4.8 μg/mL) was evaluated on Detection of deep venous thrombosis (Sensitivity 100%, Specificity 85%). A D-dimer cutoff value of 4.8 μg/mL demonstrated 100% sensitivity and 85% specificity for detecting deep venous thrombosis in pregnant women with threatened premature delivery and abortion.

synapsesocial.com/papers/6ab488fa681f7b53e3fd73c4https://doi.org/10.21203/rs.2.13557/v1
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