Allergic Pneumonitis During Chemotherapy for Tuberculosis: Report of Two Cases Due to Para-Aminosalicylic Acid

Case Reports1 January 1955ALLERGIC PNEUMONITIS DURING CHEMOTHERAPY FOR TUBERCULOSIS: REPORT OF TWO CASES DUE TO PARA-AMINOSALICYLIC ACIDROBERT J. ATWELL, M.D., JOHN A. PRIOR, M.D., F.A.C.P.ROBERT J. ATWELL, M.D.Search for more papers by this author, JOHN A. PRIOR, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-1-190 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe increasing use of streptomycin and para-aminosalicylic acid (PAS) in the treatment of pulmonary tuberculosis makes awareness of possible toxic reactions to these drugs important to the physician. Toxic effects are uncommon with present dosage schedules but do occur, and they must be recognized before serious harm is done to the patient.Finland and Weinstein1have recently reviewed the reactions to antibiotics, including streptomycin, and Warring and Howlett2have reviewed the literature concerning reactions to PAS. Both streptomycin and PAS are capable of producing reactions quite similar but, in addition, streptomycin specifically may produce eighth nerve damage, while PAS frequently...Bibliography1. FinlandWeinstein ML: Complications induced by antimicrobial agents, New England J. Med. 248: 220-226, 1953. CrossrefMedlineGoogle Scholar2. WarringHowlett FCKS: Allergic reactions to para-aminosalicylic acid, Am. Rev. Tuberc. 65: 235-249, 1952. MedlineGoogle Scholar3. MorandiOchsnerNeuenschwander LHA: Secondary effects in the course of treatment of tuberculosis with para-aminosalicylic acid, Schweiz. med. Wchnschr. 52: 1301-1304, 1951. Google Scholar4. Loeffler W: Transitory pulmonary infiltrates with eosinophilia, Schweiz. med. Wchnschr. 66: 1069, 1949. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio*Received for publication April 2, 1954.From the Ohio Tuberculosis Hospital and the Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical and High-resolution Computed Tomographic Findings in Five Patients with Pulmonary Tuberculosis Who Developed Respiratory Failure Following ChemotherapyLoeffler's Syndrome Due To Para-Aminosalicylic AcidRecurrent Pulmonary Infiltration and Pleural Effusion Due to Nitrofurantoin SensitivityHypersensitivity to para-aminosalicylic acidLung infiltrations as a complication of PAS treatmentCOMBINED HYPERSENSITIVITY REACTION TO SODIUM PARA-AMINOSALICYLATE AND ASSOCIATED ANTIBACTERIAL DRUG CONCURRENTLY ADMINISTERED*AARON A. COHEN, M.D., S. H. LAWRENCE, M.D.SEVERE SYSTEMIC REACTIONS TO PARA-AMINOSALICYLIC ACID: A CASE REPORT AND REVIEW OF THE LITERATURE*W. J. ALT, J. R. SPENGLERThe Synthetic Antimicrobial Agents: Applied Pharmacology 1 January 1955Volume 42, Issue 1Page: 190-197KeywordsAntibioticsChemotherapyDrugsHospital medicineNervesPeriodic acid SchiffPneumonitisStreptomycin ePublished: 1 December 2008 Issue Published: 1 January 1955 PDF downloadLoading ...