Key result
Cytokines drive plaque inflammation and carry key prognostic value across atherosclerosis and CAD.
Why the study?
The role and prognostic significance of cytokines in the pathogenesis and progression of atherosclerosis and coronary artery disease require comprehensive review.
This review highlights the pathophysiological role and prognostic value of cytokines in atherosclerosis and coronary artery disease.
Cytokine networks in atherosclerosis merit targeted trials; leaves open whether modulation improves outcomes.
Atherosclerosis is currently regarded as a chronic inflammatory disease that is mediated by several types of cells and molecules. Emphasis has been placed on the role of cytokines and the way they act and interact to initiate and sustain inflammation in the microenvironment of an atherosclerotic plaque. Cytokines are invariably expressed by all cells involved in the pathogenesis of atherosclerosis, act on a variety of targets exerting multiple effects and are largely responsible for the crosstalk among endothelial, smooth muscle cells, leukocytes and other vascular residing cells. In the present paper our aim is to review current information on the role of the most commonly discussed cytokines in the process of atherogenesis and to discuss the prognostic significance of these cytokines in atherosclerosis and coronary artery disease.
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Tousoulis et al. (2015) conducted a review in Atherosclerosis and Coronary Artery Disease. Cytokines was evaluated. Cytokines play a key role in initiating and sustaining inflammation in atherosclerotic plaques and have prognostic significance in atherosclerosis and coronary artery disease.
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