Key result
The sequence-independent single primer amplification (SISPA) method successfully identified six viruses from 17 clinical respiratory samples with uncharacterized cytopathic effects.
Population
17 clinical respiratory samples producing uncharacterized cytopathic effects in LLC-MK2 cells
Authors
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SISPA detects variant cardioviruses in unexplained respiratory samples; leaves open their pathogenicity and clinical relevance.
The SISPA method is useful for identifying emerging and known viruses from clinical respiratory samples that are not easily identified by standard virological methods.
Abed et al. (2009) studied Unidentified cytopathic effects in clinical respiratory samples (n=17). Sequence-independent single primer amplification (SISPA) was evaluated on Identification of viruses. The sequence-independent single primer amplification (SISPA) method successfully identified six viruses from 17 clinical respiratory samples with uncharacterized cytopathic effects.
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