What question did this study set out to answer?

To assess the relative pathogenicity and secondary transmission rates of drug-resistant compared to drug-susceptible Mycobacterium tuberculosis strains in a human population.

December 15, 2003The Journal of Infectious Diseases

Effect of Drug Resistance on the Generation of Secondary Cases of Tuberculosis

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To assess the relative pathogenicity and secondary transmission rates of drug-resistant compared to drug-susceptible Mycobacterium tuberculosis strains in a human population.
Linked IS6110 genotype patterns with drug-susceptibility profiles and epidemiologic data for 85% of culture-positive incident tuberculosis cases in San Francisco between 1991 and 1999 (N=1800).
Identified secondary transmission events by matching IS6110 genotypes and drug-resistance patterns, calculating relative secondary-case rate ratios (SR).
The overall secondary-case rate ratio for drug-resistant compared to drug-susceptible tuberculosis was 0.51 (95% CI, 0.37–0.69).
Secondary transmission was significantly reduced for isoniazid-resistant strains (SR 0.29; 95% CI, 0.15–0.57) and combined isoniazid-streptomycin-resistant strains (SR 0.10; 95% CI, 0.02–0.42), with zero secondary cases observed for multidrug-resistant strains.
Rifampin-resistant tuberculosis exhibited an increased secondary-case rate ratio of 2.33 (95% CI, 1.04–5.25), with 78% (7/9) of secondary cases occurring in HIV-positive patients.

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Implication

Cohort study reveals reduced secondary transmission of drug-resistant tuberculosis in an urban population, indicating decreased pathogenicity of resistant strains.

Cite This Study

Burgos et al. (2003) studied this question.

synapsesocial.com/papers/6ab48c3db5ba52d6b9c031da https://doi.org/10.1086/379895

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Implication

Cohort study reveals reduced secondary transmission of drug-resistant tuberculosis in an urban population, indicating decreased pathogenicity of resistant strains.

Effect of Drug Resistance on the Generation of Secondary Cases of Tuberculosis

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Discussion

Implication

Cite This Study

Effect of Drug Resistance on the Generation of Secondary Cases of Tuberculosis

Key Points

Discussion

Implication

Cite This Study

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