Key result
Novel directional electrode configurations induce strong targeted endocardial virtual electrodes in silico.
Why the study?
Implanted cardioverter defibrillators deliver strong shocks causing extra-cardiac stimulation, pain, tissue damage, and limited battery life, and anti-tachycardia pacing is often ineffective due to electrode placement.
Population
Anatomically-realistic rabbit ventricular models in silico
Comparison
Two conceptual intra-cardiac directional electrode configurations vs conventional electrode arrangements
Design
Preclinical in silico study
Authors
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May reduce ICD shock pain; hypothesis-generating for refined electrotherapies pending clinical trials.
Novel intra-cardiac directional electrode configurations may facilitate targeted far-field anti-tachycardia pacing and minimize extra-cardiac stimulation.
Connolly et al. (2018) studied Cardiac arrhythmias. Conceptual intra-cardiac directional electrode configurations was evaluated on Spatial variation of induced field and preferential excitation. In silico testing in rabbit ventricular models demonstrated that novel intra-cardiac directional electrode configurations produce strong virtual electrodes on targeted endocardial surfaces.
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