What question did this study set out to answer?

To review the immunomodulatory mechanisms of pineal and extrapineal melatonin and assess their role in the expression of seasonally dependent diseases.

January 1, 2008NeuroImmunoModulation

Immunomodulation by Melatonin: Its Significance for Seasonally Occurring Diseases

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Authors

VSVenkataramanujam SrinivasanUniversidad de Alcalá DSD. Warren SpenceUniversity of North Carolina at Chapel Hill ITIlya TrakhtThe University of Texas Health Science Center at San Antonio

Discussion

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Implication

Review demonstrates seasonal immunomodulatory actions of melatonin on human immune function, suggesting mechanisms underlying seasonal disease flares.

Key Points

To review the immunomodulatory mechanisms of pineal and extrapineal melatonin and assess their role in the expression of seasonally dependent diseases.
Reviewed literature regarding melatonin synthesis in lymphoid tissues, including bone marrow, thymus, and lymphocytes.
Assessed evidence of melatonin-regulated cellular and humoral immune pathways, cytokine cascades, and seasonal disease epidemiology.
Melatonin regulates both cellular and humoral immunity by stimulating the production of natural killer cells, monocytes, and leukocytes while shifting the T helper balance toward Th-1 responses.
Melatonin upregulates specific proinflammatory and immunoregulatory cytokines, including interleukin-2, interleukin-6, interleukin-12, and interferon-gamma, in a seasonal pattern.
Season-dependent immune modulation driven by melatonin is implicated in the recurring cyclical patterns of infectious diseases, seasonal affective disorder, and rheumatoid arthritis.

Cite This Study

Srinivasan et al. (2008) studied this question.

synapsesocial.com/papers/6ab48fc67fc930a00ef63bba https://doi.org/10.1159/000148191

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Implication

Review demonstrates seasonal immunomodulatory actions of melatonin on human immune function, suggesting mechanisms underlying seasonal disease flares.

Immunomodulation by Melatonin: Its Significance for Seasonally Occurring Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Immunomodulation by Melatonin: Its Significance for Seasonally Occurring Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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