Gene Deletions due to Ring Chromosome 16 are Associated with Low Reproductive Potential, a Novel Observation

Diminished ovarian reserve (DOR) is characterized by decreased number of oocytes associated with poor ovarian response (POR) to controlled ovarian hyperstimulation (COH). Presently, few specific known chromosomal abnormalities are associated with DOR. Ring chromosome is among the least likely genetic abnormality reported to impact female infertility. It may occurs when two breaks are created in one chromosome and the resulting ends fuse to form a ring, leading to loss of distal genetic material.