Key result
Elevated apoB and apoB/apoA-I ratio track directly with worse cardiometabolic and lipid risk profiles.
Why the study?
The apoB/apo A-I ratio has been reported as an important predictor of cardiovascular risk, superior to conventional lipid measures, but its association with cardiometabolic risk variables in adolescents needed investigation.
Are apolipoproteins A-I and B, and their ratio associated with cardiometabolic risk variables in adolescents?
Cross-Sectional (n=104)
Are apolipoproteins A-I and B, and their ratio associated with cardiometabolic risk variables in adolescents?
Apolipoprotein B and the apoB/apoA-I ratio are strongly associated with adverse cardiometabolic risk profiles in adolescents, suggesting their potential utility as early risk markers.
Supports apoB as cardiometabolic risk marker; leaves open causality and clinical utility pending longitudinal data.
INTRODUCTION: the apoB/apo A-I ratio has been reported as an important predictor of cardiovascular risk, being superior to lipids, lipoproteins and conventional lipid ratios. OBJECTIVE: to investigate the association between apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and cardiometabolic risk variables in adolescents. METHODS: this was a cross-sectional study including 104 adolescents of public schools in Recife during the months of March/April, 2013. Sociodemographic, anthropometric, clinical and biochemical variables were analysed. The apolipoproteins were analysed via Immunoturbidimetry. RESULTS: body mass index, waist circumference, waist circumference/height, triglycerides, cholesterol/HDL, and apolipoprotein B/apolipoprotein A-I declined with the progress of the percentile distribution of apolipoprotein A-I concentrations, while the HDL and apolipoprotein B increased between the first and last quartiles of the apolipoprotein A-I concentrations. Systolic blood pressure, body mass index, waist circumference, waist circumference/height, cholesterol, LDL, triglycerides, cholesterol/HDL, and LDL/HDL increased progressively in the quartile distribution of the concentrations of apolipoprotein B and apolipoprotein B/apolipoprotein A-I. Alfa-1-acid glycoprotein serum levels increased hand-inhand with the percentile progression of apolipoprotein B. CONCLUSIONS: the findings underline an important association of apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and their clinical, biochemical and anthropometric cardiometabolic risk. However, prospective studies are important to evaluate the pertinence of implementing these markers in the clinical practice.
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Albuquerque et al. (2015) conducted a cross-sectional in Cardiometabolic risk (n=104). Apolipoproteins A-I and B, and apoB/apoA-I ratio was evaluated on Cardiometabolic risk variables (BMI, waist circumference, blood pressure, lipids). Apolipoprotein B and the apoB/apoA-I ratio were positively associated with systolic blood pressure, BMI, waist circumference, and atherogenic lipid markers across quartile distributions.
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