Key result
Long-term amiodarone therapy increases hepatic attenuation on CT scans via iodine deposition.
Why the study?
Long-term amiodarone therapy leads to deposition of the drug and its metabolite in the liver, affecting hepatic attenuation on CT scans.
Does long-term amiodarone therapy cause increased hepatic attenuation on CT?
Does long-term amiodarone therapy cause increased hepatic attenuation on CT?
Long-term amiodarone therapy causes increased hepatic attenuation on CT due to iodine deposition in the liver.
Requires caution interpreting liver attenuation on CT in amiodarone patients; leaves open diagnostic implications.
Approximately 40% of the anti-arrhythmic drug, amiodarone, consists of iodine. During long-term therapy both the drug and its major metabolite, desethylamiodarone, are deposited in the liver. CT scans of patients receiving such therapy demonstrated increased hepatic attenuation.
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Patrick et al. (1984) studied this question. Long-term amiodarone therapy causes increased hepatic attenuation on CT scans due to the deposition of the iodine-rich drug and its major metabolite in the liver.
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