Key result
Social risk factors were unlikely to predict non-adherence to tyrosine kinase inhibitor therapy in adults with chronic myeloid leukemia, despite an overall non-adherence rate of 21%.
Why the study?
Do social risk factors predict non-adherence to tyrosine kinase inhibitors in patients with chronic myeloid leukemia?
Case-Control (n=151)
Do social risk factors predict non-adherence to tyrosine kinase inhibitors in patients with chronic myeloid leukemia?
Social determinants of health were unlikely to predict adherence to TKI treatment in CML patients, highlighting the need for qualitative investigation of causes rather than relying solely on statistical estimates.
Social risk factors associated with TKI nonadherence in CML; leaves open need for prospective validation before guiding interventions.
OBJECTIVE: To assess the role of social risk factors on adherence to tyrosine kinase inhibitors (TKI) therapy in chronic myeloid leukemia (CML) patients. METHODS: This is a retrospective study and eligible patients were adults with CML on TKI treatment. Cases of no adherence to treatment were confirmed during pharmacists' consultation (patient-reported adherence). Baseline characteristics between groups were compared between cases and controls groups. Risk factors identified in bivariate analysis (p<0.2) were included in multivariate model. A qualitative investigation assessed whether such predictors of non-adherence had causal relationship. RESULTS: Of 151 patients with CML consulted by pharmacists, 21% had adherence problems. Despite patients with secondary school (p=0.03), most of investigated social risk factors did not differ between groups. However, by using a qualitative approach, patients' level of education could not explain low adherence rates behavior. CONCLUSIONS: Social determinants of health, herein investigated, were unlikely to predict adherence to treatment. Regression techniques may lead to untrue statements, so future researches should consider investigating the causes, not only the statistical estimates.
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Okumura et al. (2015) conducted a case-control in Chronic myeloid leukemia (CML) (n=151). Social risk factors vs. Absence of social risk factors was evaluated on Non-adherence to tyrosine kinase inhibitor therapy. Social risk factors were unlikely to predict non-adherence to tyrosine kinase inhibitor therapy in adults with chronic myeloid leukemia, despite an overall non-adherence rate of 21%.
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