Key result
Mitral regurgitation occurs in ~3% of aortitis syndrome cases, typically presenting late with hemodynamic stress.
Why the study?
Mitral regurgitation associated with aortitis syndrome is uncommon and its characteristics and clinical course are not well described.
Case Report (n=128)
No
Mitral regurgitation is a rare complication (3.1% incidence) in the late stages of aortitis syndrome, potentially exacerbated by secondary hypertension and aortic regurgitation.
Answers are grounded in this paper and cite their sources.
Rare late MR in aortitis syndrome merits clinical awareness; leaves open need for surveillance or intervention trials.
Three patients with mitral regurgitation (MR) associated with aortitis syndrome are presented. All had multiple lesions of the large sized arteries, calcification of the aorta, mild inflammatory findings, a chronic course, and congestive heart failure. MR was observed by ventriculography in all 3 patients. Case 1 had mitral valve prolapse and secondary systemic hypertension. Case 2 showed mildly thickened mitral valve leaflets and had moderate aortic regurgitation (AR). Case 3 had massive AR. The grade of MR was moderate in Cases 1 and 2, and massive in Case 3. The left ventricle was moderately dilated in Cases 1 and 2 but contracted sufficiently and symmetrically in all 3 patients. Other than the prolapse, no significant mitral valve deformity or left ventricular asynergy was evident by ventriculography. The incidence of MR was 3.1% of 128 patients with aortitis syndrome observed in our clinic. MR may be found in the late stage of aortitis syndrome. It may be caused by a mild valvular lesion related to aortitis syndrome and be exacerbated by increased hemodynamic loads such as those which occur in secondary hypertension and AR.
No takes yet. Share an insight, caveat, or question.
Morooka et al. (1983) conducted a case report in Aortitis syndrome (Takayasu's arteritis) (n=128). Aortitis syndrome was evaluated on Incidence of mitral regurgitation. Among 128 patients with aortitis syndrome, the incidence of mitral regurgitation was 3.1%, typically presenting in the late stage of the disease and exacerbated by increased hemodynamic loads.
Synapse has enriched 10 related papers. Consider them for comparative context: