Key result
Doppler echocardiography confirms true left ventricular outflow obstruction in hypertrophic cardiomyopathy, yielding equivalent pressures.
Why the study?
The etiology of systolic left ventricular-to-aortic pressure gradients in hypertrophic cardiomyopathy remains controversial, with uncertainty whether true outflow obstruction elevates left ventricular systolic pressure.
Comparison
Doppler echocardiographic estimates of left ventricular systolic pressure versus aortic systolic pressure plus outflow tract gradient
Design
Observational case series using imaging and Doppler echocardiography
Authors
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Supports true LVOT obstruction in HCM; leaves open need for larger studies before changing practice.
Observational (n=5)
Absolute Event Rate: 187% vs 187%
Doppler echocardiography demonstrates that true left ventricular outflow tract obstruction, rather than cavity obliteration, elevates left ventricular systolic pressure in hypertrophic cardiomyopathy.
Come et al. (1988) conducted an observational in Hypertrophic cardiomyopathy (n=5). Imaging and Doppler echocardiography was evaluated on Left ventricular systolic pressure estimated by two different Doppler techniques. Doppler echocardiography showed estimated left ventricular systolic pressures by two techniques were equivalent (both 187 mm Hg), indicating true outflow obstruction in hypertrophic cardiomyopathy.
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