Why the study?
Do intraventricular gradients impede left ventricular outflow in patients with hypertrophic cardiomyopathy?
Population
59 patients undergoing cardiac catheterization, comprising 30 patients with hypertrophic cardiomyopathy and…
Comparison
Assessment of left ventricular ejection dynamics… vs Control group of 29 patients with no evidence of…
Design
Cross-sectional
Authors
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Questions whether gradients represent true obstruction in HCM; leaves open therapeutic implications pending prospective validation.
Do intraventricular gradients impede left ventricular outflow in patients with hypertrophic cardiomyopathy?
The study demonstrates that abnormal intraventricular pressure gradients and systolic anterior motion of the mitral valve do not impede left ventricular outflow in HCM, challenging the traditional concept of outflow obstruction.
Murgo et al. (1983) studied this question.
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