Key result
Patients with hypertrophic cardiomyopathy and resting intraventricular pressure gradients had a higher mean left ventricular ejection fraction (92%) compared to those without a gradient (75.5%).
Why the study?
Does an intraventricular pressure gradient impair left ventricular emptying in patients with hypertrophic cardiomyopathy?
Population
33 patients with hypertrophic cardiomyopathy
Comparison
Presence of resting or induced intraventricular… vs Absence of resting or inducible pressure gradient
Design
Cross-sectional
Authors
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Challenges assumption that gradients impair LV emptying in HCM; hypothesis-generating for cavity obliteration mechanism, needing prospective validation.
Observational (n=33)
Does an intraventricular pressure gradient impair left ventricular emptying in patients with hypertrophic cardiomyopathy?
Absolute Event Rate: 92% vs 75.5%
Higher ejection fractions and enhanced emptying with induced gradients in hypertrophic cardiomyopathy suggest that cavity obliteration, rather than outflow obstruction, is responsible for the pressure gradient.
Siegel et al. (1985) conducted an observational in Hypertrophic cardiomyopathy (n=33). Intraventricular pressure gradient vs. No resting or inducible pressure gradient was evaluated on Left ventricular ejection fraction. Patients with hypertrophic cardiomyopathy and resting intraventricular pressure gradients had a higher mean left ventricular ejection fraction (92%) compared to those without a gradient (75.5%).
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