Patients with hypertrophic cardiomyopathy and resting intraventricular pressure gradients had a higher mean left ventricular ejection fraction (92%) compared to those without a gradient (75.5%).
Observational (n=33)
Does an intraventricular pressure gradient impair left ventricular emptying in patients with hypertrophic cardiomyopathy?
Higher ejection fractions and enhanced emptying with induced gradients in hypertrophic cardiomyopathy suggest that cavity obliteration, rather than outflow obstruction, is responsible for the pressure gradient.
Absolute Event Rate: 92% vs 75.5%
Thirty three patients with hypertrophic cardiomyopathy were studied to determine whether the presence of an intraventricular pressure gradient impaired left ventricular emptying. Patients with resting gradients had a higher mean left ventricular ejection fraction (92 (6.4)%) than patients without a resting or inducible pressure gradient (75.5 (9)%). The rate and degree of emptying increased when gradients greater than 85 mm Hg were induced in two patients with insignificant mitral regurgitation. If the induced gradients had been the result of obstruction a decrease in the rate or degree of ventricular emptying would be expected. Higher ejection fractions in patients with intracavitary pressure gradients as well as enhanced rate and degree of left ventricular emptying with induced gradients are inconsistent with outflow obstruction. These findings support the concept that cavity obliteration is responsible for the pressure gradient in these patients with hypertrophic cardiomyopathy.
Siegel et al. (Fri,) conducted a observational in Hypertrophic cardiomyopathy (n=33). Intraventricular pressure gradient vs. No resting or inducible pressure gradient was evaluated on Left ventricular ejection fraction. Patients with hypertrophic cardiomyopathy and resting intraventricular pressure gradients had a higher mean left ventricular ejection fraction (92%) compared to those without a gradient (75.5%).