On the Question of Obstruction in Idiopathic Hypertrophic Subaortic Stenosis

Editorial1 October 1966On the Question of Obstruction in Idiopathic Hypertrophic Subaortic StenosisJOHN ROSS JR., M.D., F.A.C.P., JAMES H. GAULT, M.D., DEAN T. MASON, M.D.JOHN ROSS JR., M.D., F.A.C.P., JAMES H. GAULT, M.D., DEAN T. MASON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-859 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOnly 10 years have elapsed since the concept of functional obstruction to left ventricular ejection was introduced to clinical medicine (1), and in the interim the features of obstructive cardiomyopathy, or idiopathic hypertrophic subaortic stenosis, have become generally recognized. It seems certain that the increasingly frequent recognition of this disease has resulted largely from wider application of left heart catheterization techniques; nevertheless, while the diagnosis initially was based on hemodynamic features peculiar to this disease, it has become possible with increasing experience to recognize and assess the severity of this lesion on clinical grounds alone (2).Work originating in a...References1. BROCK R: Functional obstruction of the left ventricle (acquired aortic subvalvular stenosis). Guy Hosp. Rep. 106: 211, 1957. Google Scholar2. BRAUNWALDLAMBREWROCKOFFROSSMORROW ECTSDJAG: Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients. Circulation 30 (suppl. 4): 3, 1964. Google Scholar3. CRILEYLEWISWHITEROSS JMKBRIRS: Pressure gradients without obstruction. A new concept of "hypertrophic subaortic stenosis." Circulation 32: 881, 1965. CrossrefMedlineGoogle Scholar4. CROSSSALISBURY CEPF: Functional subaortic stenosis produced in animals. Amer. J. Cardiol. 12: 394, 1963. CrossrefMedlineGoogle Scholar5. WHITELEWISCRILEY RIKBJM: Nonobstructive nature of isoproterenol-induced left ventricular pressure gradients in dogs (abstract). Circulation 32 (suppl. 2): 219, 1965. Google Scholar6. HERNANDEZGREENFIELDMCCALL RRJCBW: Pressure-flow studies in hypertrophic subaortic stenosis. J. Clin. Invest. 43: 401, 1964. CrossrefMedlineGoogle Scholar7. PIERCEMORROWBRAUNWALD GEAGE: Idiopathic hypertrophic subaortic stenosis. III. Intraoperative studies of the mechanism of obstruction and its hemodynamic consequences. Circulation 30 (suppl. 4): 152, 1964. Google Scholar8. ROSSBRAUNWALDGAULTMASONMORROW JEJHDTAG: On the mechanism of the intraventricular pressure gradient in idiopathic hypertrophic subaortic stenosis. Circulation. In press. Google Scholar9. MORROWVASKOHENNEYBRAWLEY AGJSRPRK: Can outflow obstruction be induced within the normal left ventricle? Amer. J. Cardiol. 16: 540, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cardiology Branch National Heart Institute National Institutes of Health Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDynamic obstruction to left ventricular outflow: The case for its existence in hypertrophic cardiomyopathyClinical significance and therapeutic implications of the left ventricular outflow tract pressure gradient in hypertrophic cardiomyopathyMarked variability of systolic heart murmur associated with idiopathic hypertrophic subaortic stenosisClinical and Laboratory Findings in Patients with Nonobstructive Intraventricular Pressure Differences 1 October 1966Volume 65, Issue 4Page: 859-861KeywordsCardiomyopathiesCardiovascular therapyCatheterizationHeart diseasesHemodynamicsLesionsStenosis Issue Published: 1 October 1966 PDF DownloadLoading ...