Key result
AdipoR1 expression was significantly higher in cortical carcinomas and pheochromocytomas compared to benign cortical tumors (p < 0.001 for both), suggesting a regulatory role in adrenal neoplasms.
Cross-Sectional (n=128)
No
p-value: p=<0.001
Adiponectin and leptin receptors are differentially expressed across histopathologically distinct human adrenal tumors, suggesting a potential regulatory role in these neoplasms.
Adipokine receptor profiling in adrenal tumors remains hypothesis-generating; prospective studies needed before any clinical translation.
Introduction: The role of adipokines in neoplasms not related to obesity is unclear.The presence of adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) as well as the leptin receptor (Ob-R) has been recognized in human adrenal tumors.The authors of the present study were the first to compare the expression of these receptors in histopathologically distinct adrenal tumors.Material and methods: The study encompassed tissue specimens of 128 patients with adrenal tumors (28 adrenal cortical adenomas (CA), 35 cortical nodular hyperplasia tumors (CNH), 20 cortical carcinomas (CC), 40 pheochromocytomas (PHEO), 5 malignant pheochromocytomas (PHEOM)) operated on at a single clinical center.The expression of the adiponectin receptors AdipoR1 and AdipoR2 as well as the leptin receptor Ob-R was assessed by immunohistochemistry.The results were correlated with body mass index (BMI) and gender of the patients.Results: AdipoR1 expression was significantly higher in cortical cancers (p < 0.001) and pheochromocytomas (p < 0.001) as compared to benign cortical tumors.AdipoR2 expression was significantly higher in cortical carcinomas as compared to cortical adenomas and hyperplasia tumors (p = 0.01), and also significantly higher in pheochromocytomas in comparison to adrenocortical cancers (p = 0.004).Leptin receptor expression was absent or minimal in half of nodular hyperplasia tumors and adrenal cortex adenomas.This receptor's expression was significantly higher in adrenocortical cancers (p = 0.038).In pheochromocytomas this receptor was expressed more abundantly than in adrenocortical cancers (p = 0.004).Conclusions: These novel findings suggest that adiponectin and leptin receptors could play a regulatory role in human adrenal neoplasms.
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Babińska et al. (2018) conducted a cross-sectional in Adrenal tumors (n=128). Malignant adrenal tumors (cortical carcinomas and pheochromocytomas) vs. Benign cortical tumors (adenomas and nodular hyperplasia) was evaluated on AdipoR1 expression (H-score) (p=<0.001). AdipoR1 expression was significantly higher in cortical carcinomas and pheochromocytomas compared to benign cortical tumors (p < 0.001 for both), suggesting a regulatory role in adrenal neoplasms.
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