Key result
Body mass index (BMI) was significantly negatively correlated with the expression of AdipoR1, AdipoR2, and leptin Ob-R receptors in adrenal tumor tissue of patients with subclinical Cushing's syndrome.
Observational (n=120)
p-value: p=<0.001
In patients with adrenal tumors, the expression of adiponectin and leptin receptors in tumor tissue is primarily associated with BMI rather than hormonal activity.
BMI primarily associates with adipokine receptor expression over hormonal activity in adrenal incidentalomas; leaves open any causal metabolic implications.
BACKGROUND: The role of adopokines in adrenal tumors' hormonal activity remains unclear. Obesity may induce arterial hypertension, disorders of carbohydrate metabolism, and is a risk factor of cardiovascular disease. In patients with subclinical hormone secretion by the adrenal cortex or medulla the risk of metabolic disease is increased. OBJECTIVE: Authors of this retrospective study selected 78 patients with subclinical hormone secretion out of all adrenal incidentaloma patients hospitalized in the Department of Endocrinology and Internal Medicine between 1995 and 2014. METHODS: The analyzed group comprised of 38 subclinical Cushing's syndrome (SCS), 40 incidentally discovered pheochromocytoma (PHEO) and 42 patients operated due to an adrenal tumor without pathological hormonal activity. Expression of adiponectin (AdipoR1, AdipoR2) and leptin (Ob-R) receptors in adrenal tumors was assessed in relation to body mass index (BMI) and hormonal activity. RESULTS: We found statistically significant negative correlations between BMI and expression of all examined receptors in SCS patients (AdipoR1: p= 0.032; AdipoR2: p< 0.001; leptin Ob-R: p= 0.001). In PHEOs, BMI correlated negatively only with AdipoR2 (p= 0.014). CONCLUSIONS: Data obtained show that the most significant factor associated with the expression of AdipoR1, AdipoR2 and leptin Ob-R receptors in the adrenal tumor tissue is BMI, not their hormonal activity.
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Babińska et al. (2018) conducted an observational in Adrenal incidentaloma (n=120). Body mass index (BMI) was evaluated on Expression of adiponectin (AdipoR1, AdipoR2) and leptin (Ob-R) receptors in adrenal tumors in relation to BMI (p=<0.001). Body mass index (BMI) was significantly negatively correlated with the expression of AdipoR1, AdipoR2, and leptin Ob-R receptors in adrenal tumor tissue of patients with subclinical Cushing's syndrome.
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