Primary Hyperparathyroidism-associated Pancreatitis: Experience from a Tertiary Center

Introduction: Primary hyperparathyroidism (PHPT) is infrequently linked with acute or chronic pancreatitis, which demands substantial perioperative care. This study aimed to assess the clinical profile of patients with PHPT and pancreatitis. Patients and Methods: This study is a retrospective audit of prospectively maintained data of patients who were diagnosed with PHPT and pancreatitis between 2018 and 2023 in the Gastroenterology Department of DMHRC, Pune, India. Results: Of the 16 patients, 62.5% were female. The mean age (years) was 44.25 ± 12.74 (Range 16-61 years). Thirteen of them had acute pancreatitis, and 3 had acute-on-chronic pancreatitis. All had elevated or high-normal serum calcium and raised PTH levels. Eleven patients underwent parathyroidectomy with histological confirmation of adenoma. Postsurgery, these patients remained normocalcemic and experienced no further pancreatitis episodes. Conclusion: Although rare, PHPT-associated pancreatitis should be considered in patients with recurrent or unexplained pancreatitis. Surgical treatment of patients with parathyroid adenoma not only normalizes calcium levels but also prevents recurrence, highlighting the importance of early diagnosis and intervention.